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As a result, Beatrice Golomb, M.D., Ph.D., associate professor of medicine at UC San Diego School of Medicine and her team enrolled more than 1,000 adults from San Diego in order to investigate the occurrence of these side effects. Individuals with cardiovascular disease and diabetes were excluded.
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The researchers found that participants who received statins were considerably more likely to rate their energy and fatigue-with-exertion as “much worse”, than those given placebo. According to the researchers, the effect seemed stronger in participants given simvastatin. Simvastatin reduced cholesterol levels significantly.
Golomb explained: “Side effects of statins generally rise with increasing dose, and these doses were modest by current standards. Yet occurrence of this problem was not rare – even at these doses, and particularly in women.”
According to the researchers if, for example, 4 of 10 women on simvastatin reported worsened energy or exertion fatigue; 2 in 10 reported worsening in both, or rated either one as “much worse”; or if 1 in 10 participants rated energy and exertion fatigue as “much worse.”
Golomb said: “Energy is central to quality of life. It also predicts interest in activity. Exertion fatigue not only predicts actual participation in exercise, but both lower energy and greater exertion fatigue may signal triggering of mechanisms by which statins may adversely affect cell health.”
The researchers note that findings from this study should be taken into consideration by doctors in risk-benefit determinations for statins, particularly for women, people aged 70-75(even if heart disease is present), and most patients without cardiovascular disease.
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